Early Days – Concepto Blood Tests 

We offer a selection of blood tests as detailed below – please book via our website or contact us for more information.

Early Gender Test - Concepto ‘Blue or Pink’ 

• Fast and reliable results via email – usually within 3 working days from your sample being received by the lab
• Available from 6 weeks of pregnancy
• 99.9% accurate DNA-based blood test
• Processed in Concepto’s UK Laboratory

Options:

• Early Gender Blood Test - £140 - Book Now!
• Early Gender Blood Test with Early Pregnancy Scan - £199 (recommended) - Book Now!

Having an Early Pregnancy Scan ahead of the blood test is recommended to confirm the gestation of your pregnancy and to check for multiple pregnancies.

An Early Gender Test identifies the gender of your unborn baby in the early stages of pregnancy. It detects X or Y chromosomes from the fetal DNA found in a maternal blood sample. If the expectant mother’s blood has male (Y) chromosomes, it's a boy.  If it has female (X) chromosomes, it's a girl.

Please click here for more information.

NIPT - Non Invasive Prenatal Test

Concepto NIPT is a safe and non-invasive screening test that uses cell free DNA (cf DNA) found in maternal blood to detect prenatal chromosomal anomalies accurately.

Detection of Down’s syndrome (Trisomy 21), Edwards’ syndrome (Trisomy 18) and Patau’s syndrome (Trisomy 13) with over 99% sensitivity and specificity.

• Results in up to 5 working days from your sample being received by the lab
• Available from 10 weeks of pregnancy – see option to also book an Early Pregnancy Scan to provide pregnancy dating or please provide a previous scan report
• Optional gender test included (worth £140)
• Processed in Concepto’s UK Laboratory
• 3 test levels – see below for details

NIPT Standard

• Down’s Syndrome (Trisomy 21)
• Edwards’ Syndrome (Trisomy 18)
• Patau’s Syndrome (Trisomy 13)
• Optional gender test included (worth £140)

Options:

• NIPT Standard Blood Test - £265 - Book Now!
• NIPT Standard Blood Test with Early Pregnancy Scan - £330 - Book Now! 

NIPT Advance

• Down’s Syndrome (Trisomy 21)
• Edwards’ Syndrome (Trisomy 18)
• Patau’s Syndrome (Trisomy 13)
• Optional gender test included (worth £140)
• Sex chromosome anomalies (X(O) Turner Syndrome; XXY Klinefelter Syndrome; XYY Jacobs Syndrome; XXX Triple X Syndrome) – click here to view NIPT Brochure
• 6 microdeletions – click here for details.

Options:

• NIPT Advance Blood Test - £290 - Book Now!
• NIPT Advance Blood Test with Early Pregnancy Scan - £355 - Book Now!

NIPT Absolute

• Down’s Syndrome (Trisomy 21)
• Edwards’ Syndrome (Trisomy 18)
• Patau’s Syndrome (Trisomy 13)
• Optional gender test included (worth £140)
• Sex chromosome anomalies (X(O) Turner Syndrome; XXY Klinefelter Syndrome; XYY Jacobs Syndrome; XXX Triple X Syndrome) – click here to view NIPT Brochure
• 92 microdeletions – click here for details

Options:

• NIPT Absolute Blood Test - £340 - Book Now!
• NIPT Absolute Blood Test with Early Pregnancy Scan - £405 - Book Now!

Limitations of NIPT:

Concepto NIPT is not suitable for patients with:

• Maternal, fetal and/or placental mosaicism (mixtures of chromosomally normal and abnormal cells in the pregnancy).
• Balanced or unbalanced translocation and chromosomal inversion in a mother.
• Patients who have received a blood transfusion within one year prior to the testing date.
• Patients who have had transplant surgery.
• Patients who have had stem cell therapy.
• Patients who have malignancies/ metastatic cancer.

The test is not recommended in the case of vanishing twin syndrome. In these cases NIPT test can be performed only if developmental arrest/fetal demise occurred before the 8th gestational week and at least 8 weeks have passed since the developmental arrest.

The performance of the Concepto NIPT analysis may be impacted with heparin and heparin analogues.

In case of cellular immunotherapy where exogenous DNA is introduced or human serum albumin therapy, at least 4 weeks must pass from the last accepted therapy before collecting the blood sample.

Twin pregnancy limitations : For twin pregnancies, ‘High Risk’ test results apply to at least one fetus. Also, a male test result could apply to one or both fetuses; a female test result would apply to both fetuses. NIPT Advance and NIPT Absolute cannot be offered in twin pregnancies.

Non-invasive Prenatal Testing Results Explained:

Is it safe for mother and child
It involves a simple and safe blood draw from the arm of the expectant mother. Being non-invasive, it is completely safe for mother and baby.

What does a low-risk result mean?
A low risk means that there is an extremely low probability for the presence of an incorrect number of chromosomes.

What does a high-risk result mean?
A high risk means that there is a high probability for the presence an incorrect number of chromosomes analysed in each package.

What is fetal fraction?
Cell-free DNA (cfDNA) in the peripheral blood of pregnant women consists of maternal DNA and a small portion of DNA from the fetus (which is placentally derived). The percentage of DNA in the maternal blood sample that comes from the placenta is known as the fetal fraction (FF). Factors that impact FF include gestational age, multiple gestations, maternal BMI, fetal aneuploidy, maternal disease and certain medication.

What is a trisomy
Normally, all cells in the human body have 46 chromosomes, made up of 23 pairs of chromosomes. These 23 pairs of chromosomes contain all of the DNA to determine the health of the baby. Certain genetic anomalies can occur when a baby develops three copies of a particular chromosome instead of two. The risk of having a chromosomal condition increases as the mother gets older.

What is a microdeletion?
Deletion syndromes are a group of clinically recognisable disorders, characterised by a small deletion of a chromosomal segment. The size and position of the deletion determine which clinical features are manifested and how severe they are. Clinical features of microdeletions can include developmental delays and intellectual disability, growth and behavioural problems, feeding difficulties, low muscle tone, seizures, dysmorphic features and varying malformations.

What are sex chromosome aneuploidies?
Sex chromosome anomalies (SCA) occur when there is a missing, extra or partial/incomplete sex chromosome (X or Y).

Please click here to view the Concepto NIPT brochure.